Detailed view for EmuJ_000763800

Basic information

TDR Targets ID: 961448
Echinococcus multilocularis, serine:threonine protein phosphatase 6 catalytic
Source Database / ID:  GeneDB

pI: 4.6639 | Length (AA): 305 | MW (Da): 34546 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00149   Calcineurin-like phosphoesterase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 305 3fga (C) 7 309 55.00 0 1 1.74684 -1.38
6 149 4iyp (C) 10 153 61.00 0 1 0.961131 -0.35
6 289 3h63 (A) 191 480 41.00 0 1 1.53695 -1.41

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129276)

Species Accession Gene Product
Arabidopsis thaliana AT1G50370   phytochrome-associated serine/threonine protein phosphatase 1
Arabidopsis thaliana AT3G19980   phytochrome-associated serine/threonine protein phosphatase 3
Brugia malayi Bm1_03950   Serine/threonine protein phosphatase C34C12.3 in chromosomeIII
Candida albicans CaO19.12667   calcineurin-like phosphoesterase similar to S. cerevisiae SIT4 (YDL047W) type 2A-related protein phosphatase
Candida albicans CaO19.5200   calcineurin-like phosphoesterase similar to S. cerevisiae SIT4 (YDL047W) type 2A-related protein phosphatase
Caenorhabditis elegans CELE_C34C12.3   Protein PPH-6
Dictyostelium discoideum DDB_G0272118   protein phosphatase 6 catalytic subunit
Drosophila melanogaster Dmel_CG12217   Protein phosphatase V
Echinococcus granulosus EgrG_000763800   serine:threonine protein phosphatase 6 catalytic
Entamoeba histolytica EHI_147500   serine/threonine-protein phosphatase ppe1, putative
Echinococcus multilocularis EmuJ_000763800   serine:threonine protein phosphatase 6 catalytic
Homo sapiens ENSG00000119414   protein phosphatase 6, catalytic subunit
Mus musculus 67857   protein phosphatase 6, catalytic subunit
Neospora caninum NCLIV_069860   Serine/threonine protein phosphatase (EC 3.1.3.16), related
Oryza sativa 4325641   Os01g0691700
Plasmodium berghei PBANKA_0412100   serine/threonine protein phosphatase 6
Plasmodium falciparum PF3D7_0314400   serine/threonine protein phosphatase 6, putative
Plasmodium knowlesi PKNH_0827700   serine/threonine protein phosphatase 6, putative
Plasmodium vivax PVX_119815   serine/threonine protein phosphatase 6, putative
Plasmodium yoelii PY02284   Serine/threonine protein phosphatase
Saccharomyces cerevisiae YDL047W   type 2A-related serine/threonine-protein phosphatase SIT4
Schistosoma japonicum Sjp_0028950   Serine/threonine-protein phosphatase 6, putative
Schistosoma mansoni Smp_023150   serine/threonine specific protein phosphatase
Schmidtea mediterranea mk4.009019.00   Serine/threonine-protein phosphatase PP2A
Schmidtea mediterranea mk4.003114.00   Serine/threonine-protein phosphatase 6 catalytic subunit
Schmidtea mediterranea mk4.002937.03   Serine/threonine-protein phosphatase 6 catalytic subunit
Toxoplasma gondii TGME49_301010   serine/threonine protein phosphatase, putative

Essentiality

EmuJ_000763800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_301010 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 294 aa 38.8% 263 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 297 aa 38.1% 265 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 294 aa 38.8% 263 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 159 aa 39.4% 142 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 294 aa 38.8% 263 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 169 aa 35.6% 163 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000763800 (Echinococcus multilocularis), serine:threonine protein phosphatase 6 catalytic
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